Welcome to the SAPIN webserver!

SAPIN is a framework dedicated to the Structural Analysis of Protein Interaction Networks

Protein-protein interaction (PPI) networks do not always inform on direct physical interactions, or whether several proteins binding to the same protein ‘hub’ are compatible or mutually exclusive, structurally (Kim et al., 2006). Integration of structural information with PPI networks can partially solve these limitations. First, 3D structural information of homologous structures can be used to predict physical binary (domain-domain) interactions within a larger complex of proteins (e.g. experimentally identified in a co-immunoprecipitation experiment). Second, 3D structures can be used to distinguish compatible (‘AND’) from mutually exclusive (‘XOR’) binding sites.